Recombinant APC Anti-FMRP antibody [EPR23852-90] (ab318498) (2024)

Overview

• Product name

  APC Anti-FMRP antibody [EPR23852-90]
  See all FMRP primary antibodies

• Description

  APC Rabbit monoclonal [EPR23852-90] to FMRP

• Host species

  Rabbit

• Conjugation

  APC. Ex: 645nm, Em: 660nm

• Tested applications

  Suitable for: Antibody labelling, Target binding affinitymore details

• Immunogen

  Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

• General notes

  Thisconjugated primary antibodyis released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.

  For suitable applications and species reactivity, please refer to the unconjugated version of this clone.This conjugated antibody is eligible for Abtrial: learn morehere.

  This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free production

  For more information see here.

  Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

• Form

  Liquid

• Storage instructions

  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Avoid freeze / thaw cycle. Store In the Dark.

• Storage buffer

  pH: 7.40
  Preservative: 0.02% Sodium azide
  Constituents: 98% PBS, 1% BSA

• Concentration information loading...

• Purity

  Protein A purified

• Clonality

  Monoclonal

• Clone number

  EPR23852-90

• Isotype

  IgG

• Research areas

  • Neuroscience
  • Cell Type Marker
  • Neuron marker
  • Dendrite marker

  • Neuroscience
  • Cell Type Marker
  • Neuron marker
  • Synapse marker

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Other

  • Epigenetics and Nuclear Signaling
  • RNAi
  • RISC

Associated products

• Alternative Versions

  • Anti-FMRP antibody [EPR23852-90] (ab259335)
  • Anti-FMRP antibody [EPR23852-90] - BSA and Azide free (ab277489)

• Isotype control

  • APC Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab232814)

Applications

Target

• Function

  Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

• Tissue specificity

  Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells.

• Involvement in disease

  Defects in FMR1 are the cause of fragile X syndrome (FRAX) [MIM:300624]. Fragile X syndrome is a common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicl*s), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.
  Defects in FMR1 are the cause of fragile X tremor/ataxia syndrome (FXTAS) [MIM:300623]. In FXTAS, the expanded repeats range in size from 55 to 200 repeats and are referred to as 'premutations'. Full repeat expansions with greater than 200 repeats results in fragile X mental retardation syndrome [MIM:300624]. Carriers of the premutation typically do not show the full fragile X syndrome phenotype, but comprise a subgroup that may have some physical features of fragile X syndrome or mild cognitive and emotional problems.
  Defects in FMR1 are the cause of premature ovarian failure syndrome type 1 (POF1) [MIM:311360]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

• Sequence similarities

  Belongs to the FMR1 family.
  Contains 2 KH domains.

• Post-translational
  modifications

  Phosphorylated on several serine residues.

• Cellular localization

  Cytoplasm. Nucleus > nucleolus.

• Information by UniProt

• Alternative names

  • FMR 1 antibody
  • Fmr1 antibody
  • Fmr1 gene antibody

  see all

Images

Protocols

Datasheets and documents

References (0)